**8. Conclusions**

The goal of this chapter was to elucidate various options and platforms of the drug discovery process in correlation with anti-infective drugs. Where most of the discovery aspects starting from microbial resistance to target-to-lead identification through HTS strategies such as structure-based, ligand-based drug design, *in vitro* cell-based/ biochemical assays, and biological response detection techniques are covered, the detailed explanation on each subtopic may be referred using the reference section. However, the challenges in anti-infective drug discovery remain a matter of concern for future research and development using different techniques to generate chemical space such as phytochemical hybridization and incorporation of nanotechnology in HTS for ultra-efficient screening and detection of biological response.

## **Acknowledgements**

The authors are grateful to: the Director-General, Department of Health & Family Welfare, Government of Sikkim, India; the Principal, Government Pharmacy College, Sikkim, India; and the Vice-Chancellor, King George's Medical University (KGMU), Lucknow, India, for the support and encouragement for this work.
