**5. Reverse pharmacology in drug discovery for infectious diseases**

HTS bioassay-guided identification and isolation of bioactive compounds from natural biodiversity is termed as "Reverse Pharmacognosy." Similarly, isolating a chemical entity and developing a pharmaceutical product from the clinically proven herbal remedy is termed "Reverse Pharmacology." Quinine and Artemisinin are the two well-known antimalarial lead molecules identified and isolated through this approach [32] which were optimized using HTS and chemistry approaches to various antimalarial drugs with a better pharmacokinetic and pharmacodynamic profile.
