**Abstract**

Obesity is a very common health problem in almost all societies. Although obesity is a problem especially in high-income or upper-middle-income countries, it is predicted that obesity will increase rapidly in the future in developing countries. Excess body weight is associated with an increased risk for many malignancies and its impact on cancer incidence and mortality is well established. The role of obesity in the pathogenesis of endometrial cancer has been proved. The incidence of endometrial cancer is increasing due to an increasing prevalence of obesity. Approximately 57% of endometrial cancers in the United States are thought to be attributable to being overweight and obese. The mechanisms underlying the relationship between obesity and endometrial cancer have not been fully defined, however adipokines are known to stimulate cell proliferation in endometrial carcinoma. By preventing obesity and reducing its prevalence, deaths from endometrial cancer can be reduced.

**Keywords:** endometrial cancer, obesity, global epidemic, prevention
