**8. Bipolar disorders in multiple sclerosis**

Bipolar disorders and broadly mood related disorders were considered as being a primordial symptom of MS [60], as the performing of mood symptomatology was reported to be initiated previously of the manifestation of the neurological features [61].

Appealing and adjacent connections that associate energy metabolism, inflammation, and demyelination were prevalent in multiple sclerosis. Furthermore, the results of oxidative stress at the oligodendrocyte level can be located between down manifestation of oligodendrocyte genes – as noticed in psychiatric diseases and in bipolar disorders specifically – to cell destruction and brain impairments emblematic of MS [62].

The susceptibility for bipolar disorders might appear as a result of the dysfunction of the brain courses controlling emotions, motor behavior, and pleasure [63, 64].
