*4.3.1 Theiler' s murine encephalomyelitis virus (TMEV)*

Theiler's Murine Encephalomyelitis Virus, first named by Max Theiler, is a natural pathogen of black eyes, causing paralysis and encephalomyelitis. Unlike Semliki Forest virus (SFV), Theiler's murine encephalomyelitis virus infection causes clinical neurological disease in immunocompetent mice, as well as atrophy of the brain and spinal cord. In addition, myelin damage is seen in bare/bare athymic mice, indicating a direct effect of viral infection independent of immune response [73].
