*5.2.3 TLRs signaling*

After nerve injury, inflammation is an important phenomenon that must be considered. Thus, Toll-like receptors (TLRs) are key factors in initiating the immune response. A number of such receptors are expressed by SCs: TLR3, TLR4, and TLR7 [103]. Some experimental studies showed an upregulation of TLRs following nerve injury, the effect being the inflammation trigger with macrophage recruitment and activation and myelin clearance via SCs [50, 104, 105].
