**9. Phage-based vaccines**

Phage-based vaccines offer significant potential advantages by building up a stage approach with the ability to quickly switch the vaccine in response to mutations in the Coronavirus. Also, vaccines based on phages are self-fulfillment, which means they automatically activate and boost immune response, with the ability to show multiple antigens. The therapeutic use of phage in humans is well understood and has a favorable safety measures. Recent studies recommended the immune response to SARS-CoV2 could be transient and need frequent booster vaccinations to manage defensive levels of immunity [60, 61].

The possible advantages of phage-based vaccines incorporate flexibility for route of administration (mucosal and intramuscular), including a potential oral drop, adaptability to virus mutations, quick progression and cost-effectiveness. These advantages, along with the known safety profile, offer hope as a potential tool in reducing this pandemic. Moreover, countries have the potential to increase productivity rapidly. Researchers are fully committed to combat the impact of this public health crisis [60].
