**Abstract**

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is severely affecting the worldwide population. It belongs to the coronavirus family which exhibit protein constituted enveloped single-stranded RNA. These viral proteins undergo post-translational modifications (PTMs) that reorganized covalent bonds and modify the polypeptides and in turn modulate the protein functions. Being viral machinery, it uses host cells system to replicate itself and make their copes, their proteins are also subject to PTMs. Glycosylation, palmitoylation of the spike and envelope proteins, phosphorylation, of the nucleocapsid protein are among the major PTMs responsible for the pathogenesis of the viral infection phase. The current knowledge of CoV proteins PTMs is limited and need to be exploring for to understand the viral pathogenesis mechanism and PTMs effect of infection phase.

**Keywords:** SARS-CoV-2, Post-translational modifications, Protein, glycosylation palmitoylation, phosphorylation
