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**37**

**1. Introduction**

**Chapter 3**

*Shakira Ghazanfar*

**Abstract**

Understanding the Mechanism

of Action of Indigenous Target

Manipulation of Gut Microbiota

The gut associated microbiota of animal plays crucial rule in the conversion to accessible nutrients for improve animal health and well-beings. Probiotic yeast (PY) is commonly use to manipulate the gut microbial balance by inhibits the disease-causing microbes and increase the number and function of desirable microbes. PY produce many fermentation metabolites, intercellular effectors, minerals and enzymes that make it an idea nutritive feed supplement for ruminants. The mode of action of the PY is depends on the animal biological inheritance, breed, managemental condition and microbial feeding type. Therefore, PY must formulate using same ecological origin, alone with desirable target; as it would be more compatible with gut ecoysytem and would yield maximum outputs as compare to non-target or foreign probiotic (FP). Therefore, for development of the Indigenous Target Probiotic (ITP), the isolation source must be same ecological region with desirable target like improve animal health and productivity. In the situation of the increase food storage around the world, ITP may provide a useful feed supplements to improve the food production in cost effective manner as compare to FP. Probiotic effectiveness is considered to be population/breed/target specific due to difference in the feed intake, change gut microflora, different food habits and different hostmicrobial interactions. In this chapter, we will highlight the preparation of the ITP

Probiotic Yeast: Linking the

and Performance in Animals

yeast and its mode of action on animal gut microbiota.

mode of action, gastrointestinal tract, fiber digestion

**Keywords:** indigenous target probiotic (ITP), *Saccharomyces cerevisiae*,

Probiotic are the live microbial feed supplements which provide the beneficial impact on the host by producing the useful metabolites [1]. Many probiotics have been available in the market for improving animal and human health in safe and healthy way. The commercially available probiotic product contains mostly lactic acid bacteria (*Lactobacillus plantrum, L.casei etc.)* and yeast (*Saccharomyces cerevisiae*) strains [2]. The beneficial impact of present probiotics is often limited and do
