**Acknowledgements**

*Background and Management of Muscular Atrophy*

value of cytotoxicity level [32]. The medicinal plant of leaf *Abelmoschus manihot* (L.) Medik from Palu of Central Sulawesi extract, where can be used to prepare the natural antioxidant and to prepare the pharmaceutical-based natural drug with proper standardization methods. Medicinal plants are a source of important therapeutic for alleviating human ailments and the medicinal plants have bioactive compounds, which are used for curing various human disease and also play an essential role key in chronic disease to especially on spinal muscular atrophy cell system pathway [33]. The natural antioxidant as a reduces the free radical of spinal muscular atrophy, stimulates the growth of normal cells, to protects the cell against the premature and abnormal aging condition of spinal muscular atrophy, helps fight the age-related molecular degeneration of spinal muscular atrophy and the last to supports the body immune

*Graph of the cytotoxic effect of* Abelmoschus Manihot *(L.) Medik on Vero cell [32].*

The muscular atrophy recessive autosomal in neuromuscular with characterized of alpha motor neuron in the spinal cord, the neuromuscular disorders is one factor genetic of infant mortality and the spinal muscular atrophy deletion or mutation the Survival motor neuron. Spinal muscular atrophy is a defect in survival motor neuron 1 (SMN 1) and it's gene localized to 5q11.2-q13.3). SMN gene (SMN 1 and SMN 2) on chromosome 5q13 and the homozygous deletion of the SMN 1 gene result in Spinal muscular atrophy. The spinal muscular atrophy disease need of natural antioxidant as a reduces the free radical of the fiber muscle cell, stimulates the growth of normal cells, to protects the cell against the premature and abnormal aging condition of spinal muscle fiber, helps fight the age-related molecular degeneration of spinal muscular cell and the last to supports the body immune system. The medicinal plant of leaf *Abelmoschus Manihot* (L.) Medik from Palu of Central Sulawesi extract, where can be used to prepare the natural antioxidant and to prepare the pharmaceutical-based natural drug with proper standardization methods. Medicinal plants are a source of important therapeutic for alleviating

**152**

system [34, 35].

**Figure 3.**

**10. Summary**

Especially Praise the father, praise the Son, praise the spirit three in one God of glory, Majesty praise forever to the King of King my lovely Jesus Christ. But He said to me, "My grace is sufficient for you, for my power is made perfect in weakness (2 Corinthians 12:9).
