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**Chapter 9**

**Abstract**

**1. Introduction**

**147**

caused by the Herpes simplex virus.

and has antiviral and antibacterial properties (**Figure 1**).

*Hedysarum* Species from Caucasus

In the complex pharmacognostic studies of three species of the genus *Hedysarum* L., we have developed a method for quantitative determination by UV spectrophotometry, HPLC, and capillary electrophoresis of the sum of xanthones in terms of mangiferin. The technique takes into account the basic physicochemical properties of xanthones; is characterized by reproducibility, high accuracy, and simplicity; and allows conducting both a screening assessment of various raw materials containing mangiferin derivatives and standardization of the prepared vegetable raw materials. The developed methods are tested on the aboveground organs of *Hedysarum* species, which are collected and dried by taking into account the rules and requirements for the preparation of medicinal raw materials. As a result, it was found that the greatest quantitative content of the sum of xanthones in

terms of mangiferin is distinguished by the grass *H. caucasicum* M. Bieb.

**Keywords:** *Hedysarum*, xanthones, mangiferine, antiviral therapy

*Hedysarum* as an additional source of mangiferin.

(0.62 0.021%). For the first time, morphological-anatomical diagnostic signs of the species *Hedysarum caucasicum M. Bieb*., *Hedysarum daghestanicum Rupr. ex Boiss*., *Hedysarum grandiflorum Pall*. are necessary for standardization of medicinal vegetal raw materials. The results show the prospect of further investigation of

To improve modern pharmacy, the study of biologically active substances exhibiting specific pharmacological activity from the natural raw materials of plant origin is of obvious interest. In our time, the problem of obtaining antiviral and antibacterial agents of plant origin is especially acute. At the moment, the problem of chronic recurrent viral diseases is very relevant. According to WHO data, about 67% of the world's population suffer from diseases of various organs and systems

Mangiferin (2-C-β-D-glucopyranosyl-1,3,6,7-tetraoxyxanthone) belongs to the group of xanthones proper, is the most widespread representative of C-glycosides,

In species of the genus *Hedysarum*, Fabaceae, xanthones, namely mangiferin, are the main group of biologically active substances. Russian scientists have developed an antiviral drug Alpizarin, from *H. alpinum* L. and *H. flavescens* Regel & Schmalh, the active substance of which is mangiferin, which has an antiviral activity against

DNA-containing viruses (*Herpes simplex, Varicella zoster, Cytomegalovirus*), immunostimulating properties, and a bacteriostatic effect on Gram-positive and Gram-negative bacteria. VILAR (Russia) produces this in two forms of production "Alpizarin ointment" and "Alpizarin tablets." In addition to domestic drugs, the

*Serebryanaya Fatima and Imachueva Djavgarat*

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