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## Meet the editors

Angel Catalá was born in Rodeo (San Juan, Argentina). He studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a PhD in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA.

From 1985 to 2004, he served as Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CON-ICET), Argentina, and Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon (France). He is winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including *Journal of Lipids*; *International Review of Biophysical Chemistry*; *Frontiers in Membrane Physiology and Biophysics*; *World Journal of Experimental Medicine and Biochemistry Research International*; *World Journal of Biological Chemistry, Diabetes and the Pancreas; International Journal of Chronic Diseases & Therapy*; and *International Journal of Nutrition*. He is the co-Editor of *The Open Biology Journal* and associate Editor for O*xidative Medicine and Cellular Longevity*.

Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from the Integral University on his work titled 'Development and evaluation of silymarin nanoformulation for hepatic carcinoma'. Currently, he's working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. He has been teaching Pharm.D, B.Pharm, and M.Pharm students and con-

ducting research in the novel drug delivery domain. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 17 original articles published in reputed journals, 1 edited book with IntechOpen, 2 book chapters (1 with McGraw Hill Publishers and other with IntechOpen), and a number of scientific articles published in 'Ingredients South Asia Magazine' and 'QualPharma Magazine'. He is a member of the American Association for Cancer Research, Commonwealth Pharmacist Association, and the British Society for Nanomedicine. Dr. Ahmad's research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.

Contents

**Section 1**

**Section 2**

**Section 3**

Recent Advances

*and Marilena Vlachou*

Inhibitor Resistance Mechanisms

with High Potential in Drug Discovery

*Richard A. Bond and Bradley K. McConnell*

**Preface III**

Drug Transport **1**

**Chapter 1 3**

**Chapter 2 17**

Pharmaceutical Dosage Forms **47**

**Chapter 3 49**

Structure of Drug-Receptor Complex **63**

**Chapter 4 65**

**Chapter 5 89**

Liposome-A Comprehensive Approach for Researchers

Preparation and *in vitro* Characterisation of Solid Dispersion Floating Tablet by Effervescent Control Release Technique with

*by Peeush Singhal, Rajneesh Dutt Kaushik and Vijay Jyoti Kumar*

3D-Printed Modified-Release Tablets: A Review of the

*by Angeliki Siamidi, Eleni Tsintavi, Dimitrios M. Rekkas* 

Integrated Molecular Profiling as an Approach to Identify PI3K

*by Nicole L. Michmerhuizen, Jiayu Wang and J. Chad Brenner*

Allosteric Modulators for GPCRs as a Therapeutic Alternative

*by Arfaxad Reyes Alcaraz, Emilio Y. Lucero Garcia-Rojas,* 

*Sandeep Vaidya and Abhiram Kumar*

Improved Floating Capabilities

*by Mani Sharma, Jyoti Joshi, Neeraj Kumar Chouhan, Mamta N. Talati,* 

### Contents



Preface

This book covers topics ranging from the application of original structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology to basic problems significant for the field of pharmacology. Chapters are contributions by invited researchers with long-standing experience in different research areas. We hope that the material presented here is understandable to a broad audience, including not only scientists but also people with a general background in the biological sciences. This volume offers up-to-date, expert reviews of the fast-moving field of pharmacology. The book is divided into three sections: Drug Transport, Pharmaceutical Dosage Forms and Structure of Drug-Receptor Complex.

Molecular pharmacology has received increased attention in recent years. Nevertheless, due to its various forms and applications, the field requires further

investigation.

The first section contains two chapters on:

The second section contains one chapter on:

The third section contains five chapters on:

Resistance Mechanisms"

Management of Cancer"

Potential in Drug Discovery"

Capabilities"

1. "Liposome-A Comprehensive Approach for Researchers"

2. "Preparation and *in vitro* Characterisation of Solid Dispersion Floating Tablet by Effervescent Control Release Technique with Improved Floating

1. "3D-Printed Modified-Release Tablets: A Review of the Recent Advances"

1. "Integrated Molecular Profiling as an Approach to Identify PI3K Inhibitor

2. "Allosteric Modulators for GPCRs as a Therapeutic Alternative with High

4. "Fibril Formation by Glucagon in Solution and in Membrane Environments"

5. "Integrating Nanotherapeutic Platforms to Image Guided Approaches for

3. "Potassium Channels as a Potential Target Spot for Drugs"
