**Acknowledgements**

This research was funded by Ministry of Science and Technology, Taiwan, No. MOST 107-2314-B-002-217-MY3, No. MOST 108-2811-B-002-616-, No. MOST 109-2314-B-002-200-, and No. MOST 109-2811-B-002-565-; and National Taiwan University Hospital, Taiwan, No. NTUH 110-S4965.
