**3. Conclusion**

Cancer gastric is a multifactorial cancer and many factors can play a role in its incidence. In the present review, several *H. pylori* pathogenic factors, environmental factors, genetic susceptibility, and immune factor in the host were described in the contributing role in the development of cancer gastric.

Different histological types of gastric cancer and anatomic location might suggest different etiologies of gastric cancer; however, genetic predisposition and inflammatory response have a consequence in a process regulating proliferation, evasion of apoptotic development of synergistic complex for the development gastric cancer, and, eventually, metastasis.

It is necessary to know the different risk factors involved in the development of gastric cancer in order to implement better therapies and a better prognosis for patients.

### **Acknowledgements**

We acknowledgment to the Hospital Infantil de México Federico Gómez, SSA for the economic support.
