*6.3.1 Amiodarone*

Amiodarone is a mainly a class III antiarrhythmic drug but also shows class I, II, and IV antiarrhythmic properties which showed benefits in ROSC. Although, no long term benefits were observed in survival to discharge benefits by the drug administration compared to placebo [68]. Amiodarone should only be used in the case when cardioversion/defibrillation and epinephrine administration have failed to revert the fatal arrhythmias to sinus rhythm. The dosing regimen during CPR is 300 mg intravenous/intraosseous bolus followed by the second dose of 150 mg failing the initial bolus dose to convert the rhythm. After successful cardioversion, amiodarone infusion should be continued for 6 h at the rate of 1 mg/min followed by 0.5 mg/min for the next 18 h.
