**9. Conclusion**

P-gp is the protein belonging to the ABC family protein transporters with the aspect of protecting the cells and vital organs from the entry of the xenobiotics, toxins and drugs. The over-expression of the P-gp in the diseased cells leads to the therapeutic failure during the treatment regimen but the role of the P-gp for producing protective action in the brain and fetal cells are also unavoidable. Hence for an effective therapeutic aspect, the action of the P-gp and its role should be studied. For overcoming the unwanted action of the P-gp the inhibitors of the P-gp are mainly developed and the strategies for overcoming the MDR by using natural inhibitors and the formulation aspects and caused are mentioned in this chapter.

### **Author details**

Chenmala Karthika and Raman Sureshkumar\* Department of Pharmaceutics, JSS College of Pharmacy (Affiliated to JSS Academy of Higher Education and Research), Ooty, Nilgiris, Tamil Nadu, India

\*Address all correspondence to: sureshcoonoor@jssuni.edu.in; sureshcoonoor@yahoo.com

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

*P-Glycoprotein Efflux Transporters and Its Resistance Its Inhibitors and Therapeutic Aspects DOI: http://dx.doi.org/10.5772/intechopen.90430*
