**8.21 Strategies to overcome MDR**

Various novel approaches were established for the inhibition of MDR in the diseased cell lines, which includes biological, physical and chemical methods as well as ribonucleic acid (RNA), interference, micro RNA and Nanotechologies [71]. MicroRNAs are the undersized non-coding RNAs are normally not synchronised in the cancer cells; with the modification in the miRNA they have the ability to up regulate the MDR part. To alter the expression of P-gp various sequence of miRNAs such as miR-296, miR-27a, miR-298, miR-451 and miR-1253 were resolved, and there were evaluated in esophageal and breast cancer cell lines [72–74].
