**4.6 Quality control of batches of pharmaceutical powders (APIs and excipients) prepared by the same procedure**

SeDeM expert system can be applied for the determination of reproducibility of manufacturing process of pharmaceutical powder substance (API and excipients). By establishing specifications for different parameters as per SeDeM-ODT expert system, variation among different batches of a product produced by the same manufacturing process can be determined [34]. **Figure 7** shows the SeDeM diagram of different batches of glucosamine sulfate, prepared by the same manufacturing procedure.
