*2.1.4 Lubricity/stability factor*

Lubricity during compression and stability of the compressed tablets are affected by the parameters included in this factor. These are the following:


This incidence factor shows the rheological properties and stability of the powder and depends upon the intrinsic moisture and hygroscopicity of the material [14]. The low value of this incidence factor shows that the product will absorb moisture from the atmosphere, worsening its rheological properties (flow and compression) and consequently altering product stability. In case of values below the acceptable limit, the following measures are taken:


**Table 1** shows the basic parameters determined according to the SeDeM-ODT expert system along with their symbols, units, and classification into different

*SeDeM-ODT Expert System: A Solution to Challenges in Characterization of Pharmaceutical…*

**3. Methodology for powder characterization by SeDeM-ODT expert**

To determine the suitability of powder/powder blend for direct compression and bucco-dispersibility, SeDeM-ODT expert system needs 15 parameters to be found out. The individual parameters of SeDeM-ODT expert system are determined according to their respective pharmacopoeial methods, reported methods, or calcu-

Characterization of powder according to the SeDeM-ODT expert system [11, 14]

• Conversion of experimental values to "r" values by applying specific factors

**3.1 Determination/calculation of basic parameters of SeDeM-ODT expert**

Procedures for the determination of basic parameters are given below:

SeDeM-ODT expert system is based on 15 basic parameters [14] which are determined experimentally or calculated on the basis of other included parameters.

Bulk density of the powder substance is determined according to the USP using graduated cylinder method [16]. The volume of the weighed amount of powder is determined using a graduated cylinder, and the density is calculated using the

*<sup>D</sup>* <sup>¼</sup> *<sup>m</sup>*

Tapped density of powdered material is determined according to the USP by tapping known volume of powder taken in a graduated cylinder and noting the volume reduction [16]. Tapping can be carried out manually or using mechanical

where D is the density of the powder (g/mL), m is the weight of the powder (g),

*<sup>V</sup>* (1)

incidence factors.

**system**

involves the following:

**system**

*3.1.1 Bulk density*

following equation:

*3.1.2 Tapped density*

tappers.

**171**

and v is the volume of the powder (mL).

lation on the basis of other basic parameters.

*DOI: http://dx.doi.org/10.5772/intechopen.92444*

and graphical presentation of results

• Determination/calculation of basic parameters

• Calculation of various indices on the basis of "r" values
