**2.5 Anti-microbial activity of SMS**

The uncontrolled use of antibiotics has caused serious problems in human and animal health, causing that pathogens develop resistance to them, so World Health Organization considered the infections caused by pathogens resistant to drugs as a public health problem; therefore, it is necessary to find new pharmacological strategies, among which we can find natural products such as plants and fungi.

The results showed that in the case of *Escherichia coli*, the greatest inhibition zone was of 12.66 mm at a concentration of 6 mg ml−1, with treatment of *Lentinula edodes*/cedar; *Salmonella typhimurium* showed a greatest inhibition zone of 31.10 mm to a concentration of 5.12 mg mL-1, with treatment of *Pleurotus ostreatus*/ Barley straw.
