**3. Level detection in water and soil and new antibiotics**

Various studies have evaluated the presence of antibiotics in soil and water [21, 25–27], as it will see below. Some authors have measured bacterial activity, through the bacterial resistance causes by them or evaluating its concentration in fruits or leaves caused by plants translocation [25, 28]. Besides, others have used direct methods to assess their presence in the environment, using techniques such as HPLC, LCMS, or gas chromatography. As a reference work, we will mention the research of Christian et al., (2003), who evaluated many antibiotics, among which the following stand out 11 β-lactams, 8 macrolides, 3 Sulfonamides, 2 fluoroquinolones, and 4 tetracyclines.

A remarkable review of the last decade with data from the last century is the work of Thiele-Bruhn, [29], but Cristian et al. [19] publish laboratory data in the same year. However, [29], summarized chemistry data such as solubility, molecular weight, polarity or not, etc., as follows. We plotted the data from both European outstanding publish, see **Figure 2.**
